Tirado N S
University Mayor of San Andrés, San Andrés
Title: Pyrethroid exposure gentoxic, chronic effects and glutation s-transferase (GSTM1, GSTT1) genetic polymorphism in vector control workers
Biography
Biography: Tirado N S
Abstract
Pyrethroids is a class of insecticides in wide use globally. The acute effects of pyrethroid poisoning are well documented, but the possible chronic effects of low dose exposure are insufficiently described. The aim was to investigate the possible genetic damage, and the association between chronic low dose exposure to pyrethroids and diabetes or pre-diabetes. A cross-sectional study was performed among 122 exposed pesticide sprayers from public vector control programs in Bolivia and among 90 non-exposed controls. Pesticide exposure was determined by questionnaire. Blood samples were analyzed for comet assay, GSTM1, GSSTT1 polymorphisms and glycosylated hemoglobin A (HbA1c), a measure of glucose regulation and bucal cells sample for micronucleus. The results of the genotoxic test showed no significant difference between exposed and controls, only in cariorexis analysis (p<0,007). The prevalence of pre-diabetes or diabetes was 61.1% among vector control workers and 7.9% among controls raw OR 18.4 [7.8; 43.6], adjusted OR 11.8 [4.2; 33.2]. A significant positive trend was observed between cumulated pesticide exposure (total number of hours sprayed) and odds of diabetes/pre-diabetes, but only for the vector control workers who had solely used pyrethroids. Caution is warranted when interpreting the results due to the possibility of residual confounding. A healthy worker effect could explain, why a dose-response relationship was only seen for the vector control workers that had only used pyrethroids? Pre-diabetes/diabetes was associated to chronic exposure to pyrethroids. Further study is warranted.